Acetylcholine receptor

From Ganfyd

In man there are four definite pharmacological subtypes and five genetic subtypes of muscarinic receptor

1. M₁
2. M₂
3. M₃
4. M₄
5. M₅

Nicotinic receptors (NAChR) are even more complicated as members of a gene family of ligand-gated ion channels. They are composed of pentamer subunits. There are three main subtypes

1. Skeletal muscle
2. Neuronal made up of combinations of α2, α4, α6, β2 or β4 and, more rarely, α5 and α3 subunits
3. Neuronal made up of combinations of α7, α8 or α9 subunits