Activity-dependent neuroprotective protein
Coded by the ADNP gene at 20q13.13 this is a 1102 amino acid peptide which seems to be a widely expressed transcription factor. Its expression is modulated by vasoactive intestinal peptide. It contains a 8 aminio acid neuroprotective sequence davunetide.
Deficiency in animal models results in neural tube closure defects and death in utero with strong association with neuronal cell differentiation and maturation.