Acute inflammatory demyelinating polyradiculoneuropathy
Acute inflammatory demyelinating polyradiculoneuropathy (AIDP) is the commonest presentation (70% in childhood, uo to 80% of adults in first world) of Guillain-Barre syndrome. It may be associated with specific anti-ganglioside antibodies to the carbohydrate epitope (-NeuAcalpha2-8NeuAcalpha2-3Galbeta1-4Glc-) of gangliosides GM3, GD3, and GT3 but often response to plasmaparesis or immunoglobulins is not associated with known antibodies. In general it has slower progression and a prompter recovery than the rarer AMAN and AMSAN presentations (note that in the third world AMAN and AMSAN can make up to 40% of GBS) but rare very severe acute presentations rapidly progressing to minmic brain death are known.
- ↑ Usuki S, Sanchez J, Ariga T, Utsunomiya I, Taguchi K, Rivner MH, Yu RK. AIDP and CIDP having specific antibodies to the carbohydrate epitope (-NeuAcalpha2-8NeuAcalpha2-3Galbeta1-4Glc-) of gangliosides. Journal of the neurological sciences. 2005 May 15; 232(1-2):37-44.(Link to article – subscription may be required.)