Acute inflammatory demyelinating polyradiculoneuropathy

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Acute inflammatory demyelinating polyradiculoneuropathy (AIDP) is the commonest presentation (70% in childhood, uo to 80% of adults in first world) of Guillain-Barre syndrome. It may be associated with specific anti-ganglioside antibodies to the carbohydrate epitope (-NeuAcalpha2-8NeuAcalpha2-3Galbeta1-4Glc-) of gangliosides GM3, GD3, and GT3[1] but often response to plasmaparesis or immunoglobulins is not associated with known antibodies. In general it has slower progression and a prompter recovery than the rarer AMAN and AMSAN presentations (note that in the third world AMAN and AMSAN can make up to 40% of GBS) but rare very severe acute presentations rapidly progressing to minmic brain death are known.