A recombinant human alpha-galactosidase A. (see also Agalsidase beta)
IV 0.2 mg/kg body weight every other week by intravenous infusion over 40 minutes
About 25% will develop IgG antibodies but a good proportion develop immunologic tolerance.
Cautions and Interactions
- Infusion associated reactions occur in about 15%
The mature glycosylated protein is composed of 2 subunits of 398 amino acids made in a human cell line.