Agalsidase alpha
From Ganfyd
rINN: Agalsidase alpha
Other Names
Agalsidase, Replagal®, alpha-D- galactoside galactohydrolase, alpha-D-galactosidase A, alpha-galactosidase A precursor, melibiase
Pharmacological Information
Pharmacology Images
File:Agalsidase alphaMolecule.png
Agalsidase alpha Molecule
Web information on Agalsidase alpha
Relevant Clinical Literature
UK Guidance
Regulatory Literature
Other Literature
Please read pharmacological data limitations
Other Wikis
Medpedia on Agalsidase alpha (Less technical, good quality control)
Wikipedia on Agalsidase alpha (Less technical, ? quality control)
Contents |
Introduction
A recombinant human alpha-galactosidase A. (see also Agalsidase beta)
Clinical Use
Indications
Administration
IV 0.2 mg/kg body weight every other week by intravenous infusion over 40 minutes
Clinical Issues
About 25% will develop IgG antibodies but a good proportion develop immunologic tolerance.
Contra-indications
Cautions and Interactions
- Infusion associated reactions occur in about 15%
Side effects
Special advice
Pharmacology
The mature glycosylated protein is composed of 2 subunits of 398 amino acids made in a human cell line.
