Anakinra

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Anakinra is a recombinant non-glycosylated form of the human interleukin-1 receptor antagonist (IL-1Ra). It works by binding the type 1 IL-1 receptor, causing competitive inhibition, and preventing the actions of the pro-inflammatory cytokines IL-1α and IL-1β. It is excreted by the kidney, and is given as a subcutaneous injection.

Contents

Indications

Cautions

  • Increased incidence of serious infections

Contraindications

Side effects

Pharmacology

Human interleukin-1 receptor antagonist produced in Escherichia coli by recombinant DNA technology.


References