Anti-NMDAR limbic encephalitis

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Due to antibodies to the NR1 and NR2 hetromers of the NMRA receptor [1] presents with:

There is an association with teratomas such as ovarian dermoid cysts which is important as resection of the tumour is potentially curative[2]. However these antibodies have been detected in 30% of SLE patients, with or without neuropsychiatric impairments. NR2 autoantibodies are also found in patients with epilepsy (33%), non-specific encephalitis and stroke[3]. The CSF 14-3-3 protein can be raised so is not helpful in differential diagnosis excluding CJD.

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