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Antineoplaston is a term coined to decribe certain peptide chains and/or amino acid derivatives. One such antineoplaston A-10 (3-phenylacetylamino-2,6-piperidinedione) is reported to be hydrolysed to phenylactylglutamine and phenylacetylisoglutamine[1] and another antineoplaston AS2-1 has been studied as the sodium salts of phenylacetylglutamine and phenylacetic acid [2] . Some have been studied as potential treatments for malignancy [3] although historically their role has been unproven. [4] A 1999 report of a small (n=9) phase II trial, for example, found the treatment to cause signficant side effects, but provided no evidence of efficacy. [5] The overall level of evidence for antineoplastons as a treatment for cancer is inconclusive according to the USA National Cancer Institute[6] and the American Cancer Society.[7] The main - possibly the only - place offering this unproven treatment is the Burzynski clinic in Texas.


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