Aripiprazole
From Ganfyd
rINN: Aripiprazole
Other Names
Abilify®
Pharmacological Information
Pharmacology Images
Aripiprazole in the:
BNF-registration required
BNF for children-registration required
Relevant Clinical Literature
Systematic reviews from Pubmed
Other Literature
Please read pharmacological data limitations
Contents |
Introduction
Clinical Use
Indications
Administration
Atypical antipsychotic clinical issues
Contra-indications
Dementia is probably a contraindication for any antipsychotic (fair evidence for increased mortality in long term use) and has an interesting medicolegal potential as it is unclear if following recent changes in datasheets (SPCs) and warnings from the regulatory authorities (eg FDA) any manufacturer will share liability for out of licence use (off license) use in newly commenced patients. In the UK an urgent review is taking place as of 2008.
Cautions
- Cardiovascular disease
- Epilepsy
- Elderly
- Dementia - increased risk stroke definite for olanzapine & risperidone
- Driving
- Withdrawal should be gradual
- Associated with increased venous thromboembolic disease
Side-effects
- Weight gain
- Parkinsonism
- Tardive dyskinesia
- Dizziness
- Postural hypotension
- Diabetes mellitus
- Neuroleptic malignant syndrome
