Aseptic meningitis

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Inflammation of the meninges without bacterial infection. Can be caused by any virus, inflammatory condition, systemic drugs or direct irritants. Although classic teaching is that it is characterised by mononuclear cell predominance in the cerebrospinal fluid, this is not always the case and CSF polymorphonuclear cell predominance (as in bacterial meningitis) can occur[1]. Thus predictive rules for bacterial meningitis have been developed[2]. Meningitis-retention syndrome (urinary retention associated with meningitis) is occasionally noted in the literature. Some causes are:

References

  1. Negrini B, Kelleher KJ, Wald ER. Cerebrospinal fluid findings in aseptic versus bacterial meningitis. Pediatrics. 2000 Feb; 105(2):316-9.
  2. Nigrovic LE, Kuppermann N, Macias CG, Cannavino CR, Moro-Sutherland DM, Schremmer RD, Schwab SH, Agrawal D, Mansour KM, Bennett JE, Katsogridakis YL, Mohseni MM, Bulloch B, Steele DW, Kaplan RL, Herman MI, Bandyopadhyay S, Dayan P, Truong UT, Wang VJ, Bonsu BK, Chapman JL, Kanegaye JT, Malley R. Clinical prediction rule for identifying children with cerebrospinal fluid pleocytosis at very low risk of bacterial meningitis. JAMA : the journal of the American Medical Association. 2007 Jan 3; 297(1):52-60.(Link to article – subscription may be required.)
  3. Michos AG, Syriopoulou VP, Hadjichristodoulou C, Daikos GL, Lagona E, Douridas P, Mostrou G, Theodoridou M. Aseptic meningitis in children: analysis of 506 cases. PLoS ONE. 2007; 2(7):e674.(Epub) (Link to article – subscription may be required.)
  4. Kupila L, Vuorinen T, Vainionpää R, Hukkanen V, Marttila RJ, Kotilainen P. Etiology of aseptic meningitis and encephalitis in an adult population. Neurology. 2006 Jan 10; 66(1):75-80.(Link to article – subscription may be required.)
  5. Kupila L, Vuorinen T, Vainionpää R, Hukkanen V, Marttila RJ, Kotilainen P. Etiology of aseptic meningitis and encephalitis in an adult population. Neurology. 2006 Jan 10; 66(1):75-80.(Link to article – subscription may be required.)
  6. Kupila L, Vuorinen T, Vainionpää R, Hukkanen V, Marttila RJ, Kotilainen P. Etiology of aseptic meningitis and encephalitis in an adult population. Neurology. 2006 Jan 10; 66(1):75-80.(Link to article – subscription may be required.)
  7. Miller E, Andrews N, Stowe J, Grant A, Waight P, Taylor B. Risks of convulsion and aseptic meningitis following measles-mumps-rubella vaccination in the United Kingdom. American journal of epidemiology. 2007 Mar 15; 165(6):704-9.(Link to article – subscription may be required.)
  8. Moris G, Garcia-Monco JC. The challenge of drug-induced aseptic meningitis. Archives of internal medicine. 1999 Jun 14; 159(11):1185-94.
  9. Ashwath ML, Katner HP. Recurrent aseptic meningitis due to different non-steroidal anti-inflammatory drugs including rofecoxib. Postgraduate medical journal. 2003 May; 79(931):295-6.
  10. Hamrock DJ. Adverse events associated with intravenous immunoglobulin therapy. International immunopharmacology. 2006 Apr; 6(4):535-42.(Link to article – subscription may be required.)