Astrocytoma

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A moderately advanced form of glioma


Glial tumour (Glioma) classification

Classification as of 2018[1]

  • Other astrocytic tumours (often referred as “circumscribed gliomas”)
    1. WHO I
      • Pilocytic astrocytoma
    2. WHO II
      • Pleomorphic xanthoastrocytoma
    3. WHO III
      • Anaplastic pleomorphic xanthoastrocytoma
  • Diffuse astrocytic and oligodendroglial tumours (often referred as “diffuse gliomas”)
    1. WHO II
      • Diffuse astrocytoma, IDH-mutant
      • Diffuse astrocytoma, IDH-wildtype
      • Diffuse astrocytoma, NOS
      • Oligodendroglioma, IDH-mutant and 1p/19q-codeleted
      • Oligodendroglioma, NOS
    2. WHO III (anaplastic)
      • Anaplastic astrocytoma, IDH-mutant
      • Anaplastic astrocytoma, IDH-wildtype
      • Anaplastic astrocytoma, NOS
      • Anaplastic oligodendroglioma, IDH-mutant and 1p/19q codeleted
      • Anaplastic oligodendroglioma, NOS
    3. WHO IV
  • Ependymal tumours
    1. WHO I
    2. WHO II
    3. WHO II or III
    4. WHO III
  • Neuronal and mixed neuronal-glial tumours
    • Diffuse leptomeningeal glioneural tumour (WHO grade not yet assigned)
    1. WHO I
    2. WHO III

Previous up to 2016 classification:

  • Astrocytomas:
    • Grade I: Pilocytic astrocytoma (generally children only; molecular changes distinct from adult forms)
    • Grade II: Fibrillary astrocytoma
    • Grade III: Anaplastic astrocytoma
    • Grade IV: Glioblastoma (multiforme)
  • Oligodendroglioma:
    • Grade II: Oligodendroglioma
    • Grade III: Anaplastic oligodendroglioma
  • Mixed oligodendroglial/astrocytic tumours
  • Ependymomas

References