Azapropazone
From Ganfyd
rINN: Azapropazone
Other Names
Rheumox®
Pharmacological Information
Pharmacology Images
Web information on Azapropazone
Relevant Clinical Literature
UK Guidance
Regulatory Literature
Other Literature
Please read pharmacological data limitations
Other Wikis
Medpedia on Azapropazone (Less technical, good quality control)
Wikipedia on Azapropazone (Less technical, ? quality control)
Contents |
Introduction
Clinical Use
Not presently used in UK
Indications
Azapropazone was promoted for use in acute gout, on the basis of a slight uricosuric effect relative to other NSAIDs.
Administration
Oral
Clinical Issues
High incidence gastrointestinal side effects
Contra-indications
Cautions and Interactions
Side effects
Commoner important
- Upper gastro-intestinal. All NSAIDs are associated with serious gastrointestinal side effects. For non-selective NSAIDs these were most common with azapropazone and least common with Ibuprofen. Selective cyclo-oxygenase-2 inhibitors are associated with a lower risk of gastrointestinal side effects
- Dyspepsia
- Haemorrhage
- Renal failure (especially in combination with diuretics and drugs acting on angiotensin system)
- Fluid retention
Rarer Important
- Cardiovascular events. This may be related to degree of cyclo-oxygenase-2 inhibition
- Asthma
- In chronic heart failure all NSAIDS have a dose-dependent increase in risk of death and increased risk of hospitalization with some such as diclofenac and coxibs having higher hazard ratios[1]
List of NSAID side-effects - many rare
Some NSAIDs are more likely to cause these side-effects than others but they all appear to be class side-effects
- Gastro-intestinal
- Gastritis
- Duodenitis
- Duodenal ulcer
- Gastric ulcer
- Oesophagitis
- Oesophageal ulcer
- Intestinal stricture
- Haemorrhage
- Colitis
- Diarrhoea
- Nausea
- Renal
- Failure
- Fluid retention/Oedema
- Papillary necrosis
- Interstitial fibrosis
- Hypersensitivity reactions
- Asthma
- Pulmonary eosinophilia
- Rashes
- Stephen-Johnson syndrome
- Toxic epidermal necrolysis
- Photosensitivity
- Nervous system
- Headache
- Dizziness
- Vertigo
- Nervousness
- Depression
- Drowsiness
- Insomnia
- Hearing disturbances
- Tinnitus
- Aseptic meningitis
- Aggravate Parkinsonism
- Other
- Haematuria
- Hepatic damage
- Alveolitis
- Pancreatitis
