B leukotriene receptor 2

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The B leukotriene receptor 2(BLT2) is a rhodopsin class outer cell membrane receptor protein coded for at 14q11.2-q12 #(adjacent to BLT1 gene) that has less specific binding properties than BLT1 and is presently poorly understood. It seems to be expressed more in sub-acute inflammation in animal models, rather than acutely. It mediates chemotaxis of granulocytes and macrophages and known affinities are in the order:

  1. Leukotriene B4
  2. 12-epi-leukotriene B4
  3. Leukotriene B5
  4. Leukotriene B3