Basigin

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Basigin is important in spermatogenesis, embryo implantation, neural network formation and tumour progression. It is a 385 amino acid peptide coded by the BSG gene at 19p13.3. It is the membrane receptor for extracellular cyclophilin A. Importantly in terms of disease its presence on erythrocytes, where it is relatively weakly expressed as the OK blood group, turns out to be essential in falciparum malaria as it is the initial key receptor allowing erythrocyte invasion by merozoites of Plasmodium falciparum [1].

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