Other Names, such as IUPAC Name
CD147, OK blood group antigen, leukocyte activation antigen M6, collagenase stimulatory factor, extracellular matrix metalloproteinase inducer, tumour cell-derived collagenase stimulatory factor, EMMPRIN, 5F7, TCSF
Important Issues in Man
Relevant Clinical Literature
Basigin is important in spermatogenesis, embryo implantation, neural network formation and tumour progression. It is a 385 amino acid peptide coded by the BSG gene at 19p13.3.
It is the membrane receptor for extracellular cyclophilin A. Importantly in terms of disease its presence on erythrocytes, where it is relatively weakly expressed as the OK blood group, turns out to be essential in falciparum malaria as it is the initial key receptor allowing erythrocyte invasion by merozoites of Plasmodium falciparum .
- ↑ Crosnier C, Bustamante LY, Bartholdson SJ, Bei AK, Theron M, Uchikawa M, Mboup S, Ndir O, Kwiatkowski DP, Duraisingh MT, Rayner JC, Wright GJ. Basigin is a receptor essential for erythrocyte invasion by Plasmodium falciparum Nature 2011 doi:10.1038/nature10606