Basophil granulocytes are the least common leukocyte in the normal blood film. Their large distinctly basophilic staining cytoplasmic granules contain histamine and heparin. Other compounds released on activation include chondroitin sulphate, elastase, lysophospholipase and some leukotrienes and cytokines They also have a distinct immunophenotype. They are characteristically mobilised as part of the IgE mediated allergic response. Basophilia if present, suggests you should consider a haematological malignancy.
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