Beta hydroxybutyric acid

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A positional isomer of hydroxybutyric acid. Commonly, referred to as the ionised form, β-hydroxybutrate (IUPAC: 3-hydroxybutrate).

It is one of the 'ketone bodies' seen in ketoacidosis, in particular, that caused by alcoholic ketoacidosis. Ketone bodies typically exist in chemical equilibrium, but in alcoholic ketoacidosis, the depletion of NAD+ by alcohol metabolism favours β-hydroxybutyrate over acetoacetate or acetone.

It may not be detected by urine dipstick which generally detects acetoacetate. Chemical or toxicological analysis can be performed using enzymatic or other physico-chemical methods such as gas chromatography-mass spectrometry. The latter is probably preferrable in post-mortem material.[1]

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