Bisoprolol

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Contents

Introduction

Bisoprolol fumarate was the first beta-blocker that was shown conclusively to reduce mortality in heart failure. It is long acting, relatively lipid soluble and cardioselective, all propreties that are consistent with the good outcomes in clinical trials. It is used after myocardial infarction and seems helpful up to 2 years.

Clinical Use

Indications

Administration

Oral

Clinical Issues

Toxicity

Contra-indications

  • Asthma
    • However there is active research studying the issue of whether chronic administration of certain betablockers might not decrease airways hyperreactivity and inflammation[1]. Nadolol may be safe in mild asthma[2].
  • Second or third degree heart block
  • Unstable heart failure

Cautions and Interactions

Side effects

  • Bronchospasm
  • Bradycardias including induction of complete heart block
  • Hypotension
  • Blunting insulin responsiveness
  • Aggravation of psoriasis

Special advice

Pharmacology

Evidence Base

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