Bisoprolol fumarate was the first beta-blocker that was shown conclusively to reduce mortality in heart failure. It is long acting, relatively lipid soluble and cardioselective, all propreties that are consistent with the good outcomes in clinical trials. It is used after myocardial infarction and seems helpful up to 2 years.
- Second or third degree heart block
- Unstable heart failure
Cautions and Interactions
- Bradycardias including induction of complete heart block
- Blunting insulin responsiveness
- Aggravation of psoriasis