Bisphenol A

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Common Name:Bisphenol A
Other Names
4-[2-(4-hydroxyphenyl)propan-2-yl]phenol, bisphenyl A, BPA, 4,4'-dihydroxydiphenylpropane
Chemical Information
Molecular Structure
Bisphenol A Molecule
Bisphenol-A.png
Relevant Clinical Literature
Other Wikis
Wikipedia on Bisphenol A (Less technical, ? quality control)

An oestrogen mimic and free radical scavenger. Other than its endocrine disruptor toxicity[1], which may impact on human fertility at current population exposure levels[2], it may also cause obesity[3] and neurobehavioral development changes[4]. There are multiple potential routes of exposure, particularly due to leaching from certain plastics[5]. Some dental filling resins will contain it, interestingly probably those with least mutogenic potential[6]. Since the 1930s the trend internationally has been to lower allowed exposure limits. Acceptable limits remain controversial as common allowed human limits are above toxic levels in animal models[7]. This issue is under active review by WHO with many nations currently taking steps to minimise exposure in early childhood.

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Exposure limit 0.05 mg/kg bodyweight/day

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Exposure limit 50 µg/kg/day

References

  1. Vandenberg LN, Maffini MV, Sonnenschein C, Rubin BS, Soto AM. Bisphenol-A and the great divide: a review of controversies in the field of endocrine disruption. Endocrine reviews. 2009 Feb; 30(1):75-95.(Link to article – subscription may be required.)
  2. Mok-Lin E, Ehrlich S, Williams PL, Petrozza J, Wright DL, Calafat AM, Ye X, Hauser R. Urinary bisphenol A concentrations and ovarian response among women undergoing IVF. International journal of andrology. 2009 Nov 30.(Epub ahead of print) (Link to article – subscription may be required.)
  3. Sargis RM, Johnson DN, Choudhury RA, Brady MJ. Environmental Endocrine Disruptors Promote Adipogenesis in the 3T3-L1 Cell Line through Glucocorticoid Receptor Activation. Obesity (Silver Spring, Md.). 2009 Nov 19.(Epub ahead of print) (Link to article – subscription may be required.)
  4. Braun JM, Yolton K, Dietrich KN, Hornung R, Ye X, Calafat AM, Lanphear BP. Prenatal bisphenol A exposure and early childhood behavior. Environmental health perspectives. 2009 Dec; 117(12):1945-52.(Link to article – subscription may be required.)
  5. Talsness CE, Andrade AJ, Kuriyama SN, Taylor JA, vom Saal FS. Components of plastic: experimental studies in animals and relevance for human health. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 2009 Jul 27; 364(1526):2079-96.(Link to article – subscription may be required.)
  6. Arossi GA, Lehmann M, Dihl RR, Reguly ML, de Andrade HH. Induced DNA Damage by Dental Resin Monomers in Somatic Cells. Basic & clinical pharmacology & toxicology. 2009 Nov 11.(Epub ahead of print) (Link to article – subscription may be required.)
  7. Ginsberg G, Rice DC. Does rapid metabolism ensure negligible risk from bisphenol A? Environmental health perspectives. 2009 Nov; 117(11):1639-43.(Link to article – subscription may be required.)
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