Bone marrow transplantation
Bone marrow transplantation (usually more correctly haemopoietic stem cell transplantation, haemopoietic STC) is now a fairly established technique for last ditch rescue or cure with allogeneic stem cell transplantation in a number of haematological malignancies. It may also work in viral infections confined to the immune system such as AIDS. The two main types are:
- Allogeneic stem cell transplantation (also known as allograft)
- Autologous stem cell transplantation (own cells being re-transplanted)
In rough order of immune mismatch. Note that immune mismatch may be harnessed to treat the underlying condition, e.g. graft-versus-leukaemia effect in acute myeloid leukaemia.
- Monozygous twin (syngeneic)
- HLA-identical sibling
- Matched unrelated donor (MUD), usually from as a volunteer unrelated donor (VUD)
- Haplo-identical (50% match, e.g. sibiling/parent/child)
- Umbilical cord/placental stem cell
- Matching (if allogeneic)
- Harvest (from patient for autologous or donor for allogeneic)
- Conditioning - typically involves myelo-ablative chemotherapy.
This article is a stub. Please feel free to expand it and make it more encyclopaedic.
- ↑ Ashfaq K, Yahaya I, Hyde C, Andronis L, Barton P, Bayliss S, Chen YF. Clinical effectiveness and cost-effectiveness of stem cell transplantation in the management of acute leukaemia: a systematic review. Health technology assessment (Winchester, England). 2010 Dec; 14(54):iii-iv, ix-xi, 1-141.(Link to article – subscription may be required.)
- ↑ Allers K, Hütter G, Hofmann J, Loddenkemper C, Rieger K, Thiel E, Schneider T. Evidence for the cure of HIV infection by CCR5Δ32/Δ32 stem cell transplantation. Blood. 2011 Mar 10; 117(10):2791-9.(Link to article – subscription may be required.)