Breast cancer grading
Grading for breast cancer.
The grading as used in the Nottingham prognostic index is sometimes referred to as the Nottingham modification of the Bloom-Richardson system or Nottingham grade. Other synonyms include Elston grade or Elston-Ellis modification.
The NHS Breast Screening Programme web-site have a reference card with representative photomicrographs as a guide to scoring.
|Tubule formation||1 point||Tubular formation in >75% of the tumour|
|2 points||Tubular formation in 10-75% of the tumour|
|3 points||Tubular formation in <10% of the tumour|
|Nuclear pleomorphism||1 point||Nuclei with minimal variation in size and shape|
|2 points||Nuclei with moderate variation in size and shape|
|3 points||Nuclei with marked variation in size and shape|
|Mitotic count||1 point||Low|
|(varies with size of hpf)||2 points||Medium|
|Total||3-5||Low (Grade I)|
|6-7||Intermediate (Grade II)|
|8-9||High (Grade III)|