Body odour, typically due to bacterial metabolism of apocrine secretions.
Typically requires a functional ABCC11 transporter. Conversely, individuals with diminished/defective ABCC11 function due to homozygosity of 538G>A in SNP rs17822931, have a lower tendency to bromhidrosis.
- ↑ Nakano M, Miwa N, Hirano A, Yoshiura K, Niikawa N. A strong association of axillary osmidrosis with the wet earwax type determined by genotyping of the ABCC11 gene. BMC genetics. 2009; 10:42.(Epub) (Link to article – subscription may be required.)
- ↑ Martin A, Saathoff M, Kuhn F, Max H, Terstegen L, Natsch A. A functional ABCC11 allele is essential in the biochemical formation of human axillary odor. The Journal of investigative dermatology. 2010 Feb; 130(2):529-40.(Link to article – subscription may be required.)
- ↑ Yoshiura K, Kinoshita A, Ishida T, Ninokata A, Ishikawa T, Kaname T, Bannai M, Tokunaga K, Sonoda S, Komaki R, Ihara M, Saenko VA, Alipov GK, Sekine I, Komatsu K, Takahashi H, Nakashima M, Sosonkina N, Mapendano CK, Ghadami M, Nomura M, Liang DS, Miwa N, Kim DK, Garidkhuu A, Natsume N, Ohta T, Tomita H, Kaneko A, Kikuchi M, Russomando G, Hirayama K, Ishibashi M, Takahashi A, Saitou N, Murray JC, Saito S, Nakamura Y, Niikawa N. A SNP in the ABCC11 gene is the determinant of human earwax type. Nature genetics. 2006 Mar; 38(3):324-30.(Link to article – subscription may be required.)