Butorphanol

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rINN: Butorphanol

Pharmacological Information

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Butorphanol Molecule

Web information on Butorphanol

NHS Evidence on Butorphanol

DrugBank on Butorphanol

Relevant Clinical Literature

Pubmed on Butorphanol

RCT with Butorphanol

Systematic reviews of Butorphanol

Butorphanol in N Eng J Med, Lancet, JAMA, BMJ

Butorphanol in Cochrane Collaboration

TRIP Database on Butorphanol

Google Scholar on Butorphanol

Bandolier on Butorphanol

UK Guidance

SNOMED search

Nice Guidance on Butorphanol

BNF-registration required
BNF for children-registration required

UK directory of medicines

UK Medicine Guide (eg pictures of capsules)

Centre for Reviews and Dissemination databases -DARE & NHS EED (evaluates reliability of research)

Prodigy Guidance on Butorphanol

Regulatory Literature

UK SPCs of medicines with marketing authorisation

EMEA search

FDA search

Other Literature

PubChem on Butorphanol

CTD (Comparative Toxicogenomics Database) link

ChemIndustry.com link

Protein Structural Information

Biological Information (GenomeNet)

Protein Knowledgebase (UniProtKB)

Please read pharmacological data limitations

Other Wikis

Medpedia on Butorphanol (Less technical, good quality control)

Wikipedia on Butorphanol (Less technical, ? quality control)

Introduction

Butorphanol is an opioid analgesic

Clinical Use

Butorphanol , as one of the more potent opioid agonists is used as a supplement to general anaesthesia. It is a weak mu-antagonist and kappa-partial-agonist, perhaps 5-7 times as potent as morphine.

Indications

Administration

iv

Clinical Issues

Increases heart rate, arterial and pulmonary blood pressures and cardiac output

Toxicity

Contra-indications

Cautions and Interactions

• Pre-existing ischaemic heart disease

Side effects

• Nausea and vomiting
• Constipation
• Drowsiness
• Respiratory depression
• Dependence

Special advice

Pharmacology