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A transmembrane protein that is a member of the immunoglobulin supergene family coded for at 16p11.2. It has a dominant role in decreasing the threshold for antigen receptor-dependent stimulation.


Critical to regulation of B lymphocyte:

  • Development
  • Activation
  • Differentiation


Significance in disease

  • Expressed on lymphocytes in a wide range of non-Hodgkin lymphomas and CLL