(Redirected from Carcinoembryonic antigen)
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Carcino-embryonic antigen (CEA) (also known as CD66)
- High molecular weight glycoprotein (Mr 180-200 kDa) that appears to function as a cell adhesion molecule
- In some patients, it is a marker of gastrointestinal tumour burden, particularly colorectal cancer, but can be raised due to other carcinomas
- Not recommended for primary diagnosis; role is mainly in detecting recurrence
- False positives: smoking, benign liver disease, ascites, inflammatory bowel disease
- Original papers: 
- ↑ GOLD P, FREEDMAN SO. DEMONSTRATION OF TUMOR-SPECIFIC ANTIGENS IN HUMAN COLONIC CARCINOMATA BY IMMUNOLOGICAL TOLERANCE AND ABSORPTION TECHNIQUES. The Journal of experimental medicine. 1965 Mar 1; 121:439-62.
- ↑ Thomson DM, Krupey J, Freedman SO, Gold P. The radioimmunoassay of circulating carcinoembryonic antigen of the human digestive system. Proceedings of the National Academy of Sciences of the United States of America. 1969;64:161-7.