Carcino-embryonic antigen

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Carcino-embryonic antigen (CEA) (also known as CD66)

  • High molecular weight glycoprotein (Mr 180-200 kDa) that appears to function as a cell adhesion molecule
  • In some patients, it is a marker of gastrointestinal tumour burden, particularly colorectal cancer, but can be raised due to other carcinomas
  • Not recommended for primary diagnosis; role is mainly in detecting recurrence
  • False positives: smoking, benign liver disease, ascites, inflammatory bowel disease
  • Original papers: [1][2]

See Also