DNA-binding protein SMUBP-2

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Common Name:DNA-binding protein SMUBP-2
Other Names, such as IUPAC Name
ATP-dependent helicase IGHMBP2, glial factor 1, immunoglobulin mu-binding protein, cardiac transcription factor-1, GF-1, EC:3.6.4.12, EC:3.6.4.13
Biochemical Information
Molecular Structure
Important Issues in Man
Relevant Clinical Literature
UK Guidance
Other Wikis
Wikipedia on DNA-binding protein SMUBP-2 (Less technical, ? quality control)

The IGHMBP2 gene at 11q13.2-q13.4 codes for the 993 amino acid pre-cursor to DNA-binding protein SMUBP-2. This is a transcription regulator and is a 5' to 3' helicase that unwinds RNA and DNA duplices with an ATP-dependent reaction. Mutations cause HMN6, a subtype of distal hereditary motor neuronopathy.