Carnitine palmitoyltransferase I
The carnitine palmitoyltransferase I (CPT1) isoenzymes are:
- Carnitine palmitoyltransferase IA (CPT1A) coded for at 11q13 and expressed primarily in liver (and fibroblasts).
- Carnitine palmitoyltransferase IB (CPT1B) coded for at 22q13.3 and expressed in muscle
The CPT1A gene is known to be 20 exons with several associated promoter regions and and transcription factor-binding sites. The CPT1A protein is inhibited by malonyl-CoA. It is known that promoting hypothalamic CPT1 activity in animal models diminishs food intake and endogenous glucose production.
Primary carnitine palmitoyltransferase I deficiency is a serious condition presenting in neonates and early life.
Which may have potential in reducing tissue ischaemic damage by analogy include: