Casein kinase
From Ganfyd
Common Name:Casein kinase
Biochemical Information
Molecular Structure
Important Issues in Man
Relevant Clinical Literature
UK Guidance
Other Wikis
Medpedia on Casein kinase (Less technical, good quality control)
Wikipedia on Casein kinase (Less technical, ? quality control)
Casein kinase is actually a group of human enzymes that phosphorylate a large number of proteins as part of the Wnt pathway. They include:
- Casein kinase I isoform alpha ( CK1, CKI-alpha, EC 2.7.11.1) coded for by the gene CSNK1A1 coded for at 13q13 which phosphorylates CTNNB1 on 'Ser-45' and interacts with axin complexes. It binds ATP and nucleotides
- Casein kinase I isoform delta (CKId, CKI-delta, EC 2.7.11.1) coded for by the gene CSNK1D coded for at 17q25 which is a central component of the circadian clock
- Casein kinase I isoform epsilon (CKIe, CKI-epsilon, EC 2.7.11.1) coded for by the gene CSNK1E at 22q12-q13 another component of the circadian clock and phosphorylates DVL1 in the Wnt pathway.
- Casein kinase I isoform gamma 1 (CKI-gamma-1) coded for by the gene CSNK1G1 at 15q22.1-q22.31
- Casein kinase I isoform gamma 2 (CKI-gamma-2) coded for by the gene CSNK1G2 at 19p13.3
- Casein kinase I isoform gamma 3 (CKI-gamma-3) coded for by the gene CSNK1G3 at 5q23
- Casein kinase II which has subunits:
- Casein kinase II subunit alpha 1 (CKII, EC 2.7.11.1) coded for by gene CSNK2A1 at 20p13 which is known after UV radiation to phosphorylate'Ser-392' of the p53 tumour suppressor gene.
- Casein kinase II subunit alpha 2 coded for by gene CSNK2A2 at 16p13.3-p13.2.
- Casein kinase II subunit beta (CK II beta, phosvitin, G5a) coded for by gene CSNK2B (G5A) at 6p21.3.
