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Caspase-3, a 277 amino acid pro-peptide is coded by the CASP3 gene at 4q35 and is a member of the peptidase C14A protein family. The prototype caspase involved in apoptosis it is cleaved by granzyme B, caspase-6, caspase-8 and caspase-10 into caspase-3 subunit p17 and caspase-3 subunit p12 which form an anti-parallel arranged heterodimer of the 4 subunits. These subunits can also form enzyme complexs with the cleavage products of caspase-7. Post-translational modification includes:

Its own enzymatic activation functions include: