Cataplexy

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Web Resources for Cataplexy
Relevant Clinical Literature
Pubmed on Cataplexy
RCT with Cataplexy   from Pubmed
Systematic reviews of Cataplexy   from Pubmed
Cataplexy in N Eng J Med, Lancet, JAMA, BMJ   from Pubmed
Cataplexy in Cochrane Collaboration   from Pubmed
TRIP Database on Cataplexy
Google Scholar on Cataplexy
Bandolier on Cataplexy
UK Guidance
NeLH on Cataplexy
NHS Evidence on Cataplexy
Centre for Reviews and Dissemination databases -DARE & NHS EED (evaluates reliability of research)
Nice Guidance on Cataplexy
Prodigy Guidance on Cataplexy
Other Wikis
Medpedia on Cataplexy (Less technical, good quality control)
Wikipedia on Cataplexy (Less technical, ? quality control)

Cataplexy is diagnostic of narcolepsy[1] and is caused by deficient hypocretin transmission and is characterised by:

  • Sudden and transient (less than 2 minutes) loss of muscle tone
  • Triggering by emotions (laughing or crying)
  • Usually bilateral and all striated muscles but may be limited especially to head and neck or dysarthria
  • Deep tendon reflexes abolished during attack
  • Worsens with sleep deprivation

Differential diagnosis

Treatment

References

  1. ↑ Dauvilliers T,Arnulf I,Mignot E. Narcolepsy with cataplexy. The Lancet 2007; 369:499-511 link requires registration
  2. ↑ Billiard M, Bassetti C, Dauvilliers Y, Dolenc-Groselj L, Lammers GJ, Mayer G, Pollmacher T, Reading P, Sonka K; EFNS Task Force. EFNS guidelines on management of narcolepsy. Eur J Neurol. 2006;13(10):1035-48
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