Category:Anti-TNF antibody/Sideeffects

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  • Latent tuberculosis should be excluded[1]
  • Withdrawal of the anti-TNF therapy in a secondary lung malignancy that expressed TNF receptors lead to tumour regression[2]
  • Infections, including severe sepsis (odds ratio for serious infection 2.0 (95% CI, 1.3-3.1), number needed to harm 59 (95% CI, 39-125) within a treatment period of 3 to 12 months[3]).
  • Malignancy (odds ratio for malignancy 3.3 (95% CI, 1.2-9.1) number needed to harm 154 (95% CI, 91-500) for 1 additional malignancy within period of 6 to 12 months)[4], including an association with hepatosplenic T-cell lymphoma in patients also on mercaptopurines.[5]

References

  1. ↑ Theis VS, Rhodes JM. Review article: minimizing tuberculosis during anti-tumour necrosis factor-alpha treatment of inflammatory bowel disease. Alimentary pharmacology & therapeutics. 2008 Jan 1; 27(1):19-30.(Link to article – subscription may be required.)
  2. ↑ Lees CW, Wallace WAH, Satsangi J. Resolution of Non-small-Cell Lung Cancer after Withdrawal of Anti-TNF Therapy. NEJM 2008;359:320-1
  3. ↑ Bongartz T, Sutton AJ, Sweeting MJ, Buchan I, Matteson EL, Montori V. Anti-TNF antibody therapy in rheumatoid arthritis and the risk of serious infections and malignancies: systematic review and meta-analysis of rare harmful effects in randomized controlled trials. JAMA : the journal of the American Medical Association 2006;295(19):2275-85. (Direct link – subscription may be required.)
  4. ↑ Bongartz T, Sutton AJ, Sweeting MJ, Buchan I, Matteson EL, Montori V. Anti-TNF antibody therapy in rheumatoid arthritis and the risk of serious infections and malignancies: systematic review and meta-analysis of rare harmful effects in randomized controlled trials. JAMA : the journal of the American Medical Association 2006;295(19):2275-85.(Direct link - subscription may be required.)
  5. ↑ Rosh JR, Gross T, Mamula P, Griffiths A, Hyams J. Hepatosplenic T-cell lymphoma in adolescents and young adults with Crohn's disease: A cautionary tale? Inflamm Bowel Dis 2007. (Direct link – subscription may be required.)

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