Loop diuretics inhibit renal tubular reabsorption of sodium from the ascending limp of the loop of Henle and are powerful diuretics. They act on the act on the Na+/K+/Cl- cotransporter. The most commonly used are furosemide and bumetanide. Ethacrynic acid is rarely used.
They have a major role in the symptomatic treatment of heart failure.
With adequate salt and fluid load their action can be used to promote renal excretion of calcium
They have weak anti hypertensive actions but will enhance the hypotensive effects of say ACE inhibitors.
Some studies have shown that in elderly patients, a small dose of loop diuretic eg Bumetanide 1 mg given 6 hrs prior to bedtime reduced Nocturia
- ↑ Steele TH, Oppenheimer S. Factors affecting urate excretion following diuretic administration in man. The American journal of medicine. 1969;47:564-74.
- ↑ Janssens HJ, van de Lisdonk EH, Janssen M, van den Hoogen HJ, Verbeek AL. Gout, not induced by diuretics? A case-control study from primary care. Annals of the rheumatic diseases. 2006;65:1080-3. (Direct link – subscription may be required.)
- ↑ Hopkinson N, Doherty M. In patients with chronic cardiac failure who have diuretic induced gout, are certain diuretics less prone at causing problems? British journal of rheumatology. 1991;30:225.