Cathepsin K

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Common Name:Cathepsin K
Other Names, such as IUPAC Name
Cathepsin O, cathepsin O2, cathepsin X, EC:3.4.22.38
Biochemical Information
Molecular Structure
PubChem on Cathepsin K
CTD (Comparative Toxicogenomics Database) on Cathepsin K
Chemical Information on Cathepsin K
Protein Structural Information on Cathepsin K
Biological Information (GenomeNet) on Cathepsin K
Protein Knowledgebase (UniProtKB) on Cathepsin K
Online Mendelian Inheritence in Man (OMIM) on Cathepsin K
Important Issues in Man
Data limitations
Relevant Clinical Literature
Pubmed on Cathepsin K
RCT with Cathepsin K
Systematic reviews of Cathepsin K
Cathepsin K in N Eng J Med, Lancet, JAMA, BMJ
Cathepsin K in Cochrane Collaboration
TRIP Database on Cathepsin K
Google Scholar on Cathepsin K
Bandolier on Cathepsin K
UK Guidance
NHS Evidence on Cathepsin K
Centre for Reviews and Dissemination databases -DARE & NHS EED (evaluates reliability of research)
Nice Guidance on Cathepsin K
Prodigy Guidance on Cathepsin K
Other Wikis
Medpedia on Cathepsin K (Less technical, good quality control)
Wikipedia on Cathepsin K (Less technical, ? quality control)
Cathepsin K is the processed form of the 329 amino acid peptide preprocathepsin coded by the CTSK gene at 1q21.3. It is a potent cysteine endoprotease for fibrinogen at acid pH and appears to have an important role in extracellular matrix degradation by osteoclasts. It is also expressed in some some hypertrophic chondrocytes. Inhibiting cathepsin K is being targeted as a means of maintaining bone mineral density in osteoporosis.

Mutations of the gene cause pycnodysostosis which is an autosomal recessive osteochondrodysplasia with osteosclerosis and short stature.

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