Chloroquine

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Contents

Introduction

A quinoline of choice in treating malaria but resistance has been developing. It is also used as an immunosuppressant. It may be active against ebola virus[1] .

Clinical Use

  • Falciparum malaria
  • Also active against P. malariae, P. vivax and P. ovale infections

Indications

Administration

See manufacturers recommendations for malaria Oral in immunosuppression adult dose is usually 250 mg chloroquine phosphate daily

iv

Clinical Issues

Contra-indications

Cautions and Interactions

At high dose throughout pregnancy visual loss, ototoxicity and cochlear-vestibular dysfunction may result in the foetus

Side effects

  • Hypotension
  • Cardiomyopathy.
  • Seizures
  • Psychosis
  • Retinal degeneration
  • Nausea, vomiting, diarrhoea, abdominal cramps
  • Headache.
  • Bone marrow depression, aplastic anaemia, agranulocytosis, thrombocytopenia, neutropenia.
  • Hepatitis
  • Rash, pigmentation
  • Tinnitus, deafness.
  • Hypoglycaemia
  • Myopathy
  • Pulmonary fibrosis

Special advice

Pharmacology

It is a reasonably active platelet-activating factor inhibitor.

References