- Falciparum malaria
- Also active against P. malariae, P. vivax and P. ovale infections
See manufacturers recommendations for malaria Oral in immunosuppression adult dose is usually 250 mg chloroquine phosphate daily
- Co-administation with amiodarone
Cautions and Interactions
At high dose throughout pregnancy visual loss, ototoxicity and cochlear-vestibular dysfunction may result in the foetus
- Retinal degeneration
- Nausea, vomiting, diarrhoea, abdominal cramps
- Bone marrow depression, aplastic anaemia, agranulocytosis, thrombocytopenia, neutropenia.
- Rash, pigmentation
- Tinnitus, deafness.
- Pulmonary fibrosis
It is a reasonably active platelet-activating factor inhibitor.
- ↑ Ekins S, Freundlich JS, Coffee M. A common feature pharmacophore for FDA-approved drugs inhibiting the Ebola virus. F1000Research. 2014; 3:277.(Epub) (Link to article – subscription may be required.)