Cholesterol hypothesis of atherosclerosis
The cholesterol hypothesis of atherosclerosis (sterol hypothesis of atherogenesis) was refined by Frantz and Moore in 1969. It evolved from the postulation by Adams, Bayliss and Ibrahim in 1962 as to why cholesterol accumulated in the media of the arterial vessel wall into assuming this was the underlying bad thing. They noted the anoxic environment devoid of functional enzymes that, in due course, became the oxidative hypothesis of atherosclerosis. The original observation of cholesterol in atheromatous vessels is attributed to Mettenheimer in 1857 although Virchow had done some similar work by 1854. Windaus showed the substance was cholesterol in 1907, although actually most is cholesterol esters such as cholesterol oleate as demonstrated by Schonheimer. Schonheimer showed the relationship with age. With the development of statins and, much later, directed-biologics, directed-cholesterol-lowering was shown to be effective.
- ↑ Frantz ID, Moore RB. The sterol hypothesis in atherogenesis. The American journal of medicine. 1969 May; 46(5):684-690.(Print) (Link to article – subscription may be required.)
- ↑ ADAMS CW, BAYLISS OB, IBRAHIM MZ. A hypothesis to explain the accumulation of cholesterol in atherosclerosis. Lancet (London, England). 1962 Apr; 1(7235):890-892.(Print) (Link to article – subscription may be required.)
- ↑ Witztum JL. The oxidation hypothesis of atherosclerosis. Lancet (London, England). 1994 Sep; 344(8925):793-795.(Print) (Link to article – subscription may be required.)