Chorea is characterised by irregular, involuntary movements, particularly of the distal limb musculature.
In its mildest form, choreiform movement can be integrated into voluntary movement, and its appearance can therefore be disguised. However, gross changes of limb or body position are seen in the more severe forms.
Any disease that can affect basal ganglia:
- Hereditary diseases:
- Paraneoplastic syndrome
- Metastases to basal ganglia
- Senile chorea (care - in one study almost 50% had late onset Huntington's chorea and less than 10% so labeled were unexplained on appropriate testing)
Directed towards suspected cause based on history and examination
- Antipsychotics - block dopamine receptors e.g. haloperidol
- Dopamine depleting agents - tetrabenazine