Chronic inflammatory demyelinating polyradiculoneuropathy

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Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a condition thought to be similar to Guillain Barré syndrome, but far more indolent. A variant is multifocal acquired demyelinating sensory and motor neuropathy (MADSUM) and it is closely related to multifocal motor neuropathy (MMN). Treatment is with immunogobulin or plasma exchange. Some respond to steroids and other immunosuppressives including biologics can work. Anti-ganglioside antibodies may be found.

Pathophysiology

Interestingly a pro-inflammatory protein, originally identified in multiple sclerosis, named MSRV-Env and encoded by Human endogenous retroviruses HERV-W is disproportionately expressed in those with CICP[1].

Treatment

Up to 6 months intravenous immunoglobulin (IVIg) is superior to intravenous methylprednisolone[2].

References