Chronic inflammatory demyelinating polyradiculoneuropathy
Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a condition thought to be similar to Guillain Barré syndrome, but far more indolent. A variant is multifocal acquired demyelinating sensory and motor neuropathy (MADSUM) and it is closely related to multifocal motor neuropathy (MMN). Treatment is with immunogobulin or plasma exchange. Some respond to steroids and other immunosuppressives including biologics can work. Anti-ganglioside antibodies may be found.
Interestingly a pro-inflammatory protein, originally identified in multiple sclerosis, named MSRV-Env and encoded by Human endogenous retroviruses HERV-W is disproportionately expressed in those with CICP.
- ↑ Faucard R, Madeira A, Gehin N, Authier FJ, Panaite PA, Lesage C, Burgelin I, Bertel M, Bernard C, Curtin F, Lang AB, Steck AJ, Perron H, Kuntzer T, Créange A. Human Endogenous Retrovirus and Neuroinflammation in Chronic Inflammatory Demyelinating Polyradiculoneuropathy. EBioMedicine. 2016 Apr; 6:190-8.(Link to article – subscription may be required.)
- ↑ Nobile-Orazio E, Cocito D, Jann S, Uncini A, Beghi E, Messina P, Antonini G, Fazio R, Gallia F, Schenone A, Francia A, Pareyson D, Santoro L, Tamburin S, Macchia R, Cavaletti G, Giannini F, Sabatelli M. Intravenous immunoglobulin versus intravenous methylprednisolone for chronic inflammatory demyelinating polyradiculoneuropathy: a randomised controlled trial. The Lancet. Neurology. 2012 Jun; 11(6):493-502.(Link to article – subscription may be required.)