Ciprofloxacin

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Ciprofloxacin is a quinolone antibiotic.

Contents

Properties

It has excellent bio-availbility and is well absorbed orally. Therefore, in a patient with a functioning gut, there is no advantage in using the more expensive intravenous form. Calcium supplements and foods fortified with calcium can reduce absorption.[1]

Disadvantages

  • There is a strong association with the O27 ribotype of Clostridium difficile and hospitals that have restricted use of it have seen a reduction in morbidity from Clostridium difficile.
  • There is an association with MRSA.

Contraindications

Adverse Effects

  • Seizures (+/- predisposing condition)
  • Tendonitis
  • Arthropathy in immature animals - so avoided in children (except nalidixic acid) unless extenuating circumstances (only reversible musculoskeletal symptoms have been reported)
  • Photosensitivity
  • Acute kidney injury (association - doubles relative risk)
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