It has excellent bio-availbility and is well absorbed orally. Therefore, in a patient with a functioning gut, there is no advantage in using the more expensive intravenous form. Calcium supplements and foods fortified with calcium can reduce absorption.
- Penetrates soft tissue well
- One of the few oral agents with anti-pseudomonal activity
- Poor streptococcal cover
- There is a strong association with the O27 ribotype of Clostridium difficile and hospitals that have restricted use of it have seen a reduction in morbidity from Clostridium difficile.
- There is an association with MRSA.
- Myasthenia gravis (may precipitate initial diagnosis)