Cirrhosis

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Cirrhosis is fibrogen scarring of the liver as a result of a chronic hepatotoxic process. Replacement of hepatocytes with fibrous scarring reduces the functional capacity of the liver, in particular its role in synthesis and elimination. Liver function is also adversely affected by the loss of the normal liver architecture and may lead to portal hypertension.

Strictly speaking, cirrhosis is a histological diagnosis, after examining liver biopsy specimens.

Causes

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