Web Resources for Clark level
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Wikipedia on Clark level (Less technical, ? quality control)
UpToDate® on Clark level (Technical, SUBSCRIPTION)
A measure of the depth of invasion of a malignant melanoma according to the layer of skin it has invaded into.
|Level||Depth of Invasion|
|I||All tumour cells are above the basement membrane. In situ melanoma by definition.|
|II||The neoplastic cells have broken through the basement membrane and extended into the papillary dermis but have not gone to the reticular dermis. Allows for occasional cells or nests of tissue straying into the reticular dermis.|
|III||Tumours cells at the interface between the papillary and reticular dermis.|
|IV||Distinct invasion of tumour into the reticular dermis. Allows for isolated intrusion of cells between the collagen bundles of the upper reticular dermis.|
|V||Invasion of neoplastic cells into the subcutaneous tissue.|
- ↑ Balch CM, Murad TM, Soong SJ, Ingalls AL, Halpern NB, Maddox WA. A multifactorial analysis of melanoma: prognostic histopathological features comparing Clark's and Breslow's staging methods. Annals of surgery. 1978 Dec; 188(6):732-42.
- ↑ Marghoob AA, Koenig K, Bittencourt FV, Kopf AW, Bart RS. Breslow thickness and clark level in melanoma: support for including level in pathology reports and in American Joint Committee on Cancer Staging. Cancer. 2000 Feb 1; 88(3):589-95.