Not really related to any other antibiotic! Blocks protein synthesis. Its particular advantages are that it is probably better than penicillin (at least in animal models) for treating Group A streptococcus (GAS), even though penicillin resistance is unknown in GAS, owing to the Eagle effect. Usual use is severe anaerobic infections.
Also has theoretical advantage in toxin mediated disease by its effect on protein synthesis (anti-exotoxin activity), so consider in toxic shock syndrome, scalded skin syndrome, scarlet fever, necrotizing Panton-Valentin leucocidin (PVL)-positive CA-MRSA-complicated pneumonia.
Oral Tastes foul, crushed tablets may be more acceptable to children than suspension. IV
Associated with Clostridium difficile pseudomembranous colitis/diarrhoea, not surprisingly given its spectrum.
Many isolates of community acquired MRSA are sensitive to clindamycin, but inducible resistance is increasingly seen. A D-test should be done - if positive, then resistance may evolve during treatment. Further it should not usually be given alone.
Binds to the 50S ribosomal subunit of rRNA so inhibiting the initiation of peptide-chain synthesis.