Coagulation cascade

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The coagulation cascade, made up of the intrinsic and extrinsic pathways was a conceptual breakthrough in understanding how the coagulation process acts as a biologic amplifier. This is a flawed but useful classic model which describe the proteolytic cascades that result over a period of 4 to 8 minutes in normal blood clotting. This process is better described as the coagulation and fibrinolysis pathway or network, and while subject to amplification as implied with the term cascade normally should be regarded as homeostatic and only pathologically subject to the chaos theory implications of the term cascade.