Coenzyme Q 10 (also known as Ubiquinone, although actually it is one of many ubiquinones) is a naturally occurring enzyme cofactor found in mitochondria. It can be obtained from diet or food supplements although it is also produced endogenously. The body uses it to promote cell growth and to protect cells from damage that could lead to cancer. It can be depleted by statins. Stopping the statin solves the problem with a normal diet and metabolism, although clinical trials suggest it might have a role if the statin is to be continued in those with muscle pain. As of 2007 Bandolier has summarised for convenience the evidence base for use in hypertension, migraine. and statin myopathy and notes the absence of registered clinical trials likely to tell us more in the near future. Its only definite indication is where a patient has one of the at least five known phenotypes associated with the rare autosomal recessive CoQ deficiency.
A large health food fad based on this exists.
- Effect of Supplemental Antioxidants Vitamin C, Vitamin E, and Coenzyme Q10 for the Prevention and Treatment of Cardiovascular Disease
- Effect of the Supplemental Use of Antioxidants Vitamin C, Vitamin E, and Coenzyme Q10 for the Prevention and Treatment of Cancer
- Potential uses for coenzyme Q10
- ↑ Caso G, Kelly P, McNurlan MA, Lawson WE. Effect of coenzyme q10 on myopathic symptoms in patients treated with statins. The American journal of cardiology 2007;99(10):1409-12. (Direct link – subscription may be required.)
- ↑ Co-enzyme Q and hypertension. Bandolier 161 2007;14(7):5-7
- ↑ Co-enzyme Q and migraine Bandolier 161 2007;14(7):5
- ↑ Co-enzyme Q and statin myopathy. Bandolier 161 2007;14(7):6