Cord colitis syndrome

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Cord colitis syndrome (CCS) is a form of colopathy, typically associated with diarrhoeal symptoms, occurring after haematopoietic stem cell transplantation using umbilical cord stem cells. The pathogenesis is not entirely clear. Bradyrhizobium bacteria have been implicated,[1] but this may represent contamination. The symptoms may be indistinguishable from graft-versus-host disease (GvHD). Distinguishing between the two entities is important because CCS is treated with antibiotics, while GvHD is treated with increased immunosuppression.