Cysteinyl leukotriene receptor 1
The cysteinyl leukotriene receptor 1(Type 1 cysteinyl leukotriene receptor,CysLT1) coded for at Xq13-q21 is a rhodopsin class outer cell membrane receptor protein stimulated by the cysteinyl leukotrienes in this order of affinity:
- Sustained bronchoconstriction
- Mucus secretion
- Oedema in airways
Expression can be mediated by type 2 helper T-cell cytokines which may explain asthma aggravated by aspirin sensitivity
Specific antagonists have been developed.