Cytokine release syndrome

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Cytokine release syndrome is usually milder than a cytokine storm and can be induced by overwhelming infection or toxaemia. However it usually is used to describe a reaction to a drug that demodulates the immune system. It is associated with immune activation and can have many serious consequences such as pulmonary oedema, renal failure or of course the multi-organ failure of cytokine storm. A spectacular example of the latter occured with the first human administration ofTGN1412.