Analogue of the nucleoside cytidine. Used in the treatment of myelodysplastic syndrome. It is incorporated into DNA during DNA replication, but once incorporated resists methylation, potentially reversing hypermethylated (inactivated) tumour suppressor genes.
- ↑ Kantarjian H, Issa JP, Rosenfeld CS, Bennett JM, Albitar M, DiPersio J, Klimek V, Slack J, de Castro C, Ravandi F, Helmer R, Shen L, Nimer SD, Leavitt R, Raza A, Saba H. Decitabine improves patient outcomes in myelodysplastic syndromes: results of a phase III randomized study. Cancer. 2006 Apr 15; 106(8):1794-803.(Link to article – subscription may be required.)