Demyelination

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Demyelination is the loss of myelin around nerve axons. A large number of diseases could cause this of which the commonest where myelin is specifically targeted are multiple sclerosis and Guillain-Barre syndrome. It is very common in the elderly brain due to ischaemic and neurodegenerative pathology. Trauma, toxins, infections and metabolic deficiency can cause it. It can be suggested by slowing in nerve axon transmission on electrophysiological studies and with changes in relaxation time on magnetic resonance imaging. Demyelinating syndrome can presented in conditions such as SLE with five presentationsERROR: Download of reference details rejected. Click on the link - PMID:29320844</ref>[1]:

  1. Neuromyelitis optica
  2. Neuromyelitis optica spectrum disorders
  3. Cerebral demyelination
  4. Brainstem demyelination
  5. Clinically isolated syndromes

Other causes include:

References

  1. ERROR: Download of reference details rejected. Click on the link - PMID:28159705