Dengue virus (DENV) is a single-stranded, positive-sense RNA icosahedral virus that causes dengue fever. There are 4 serotypes:
- Dengue virus type 1
- Dengue virus type 2
- Dengue virus type 3
- Dengue virus type 4
They infect cells through viral E glycoprotein receptor-mediated endocytosis and fusion from within acidic endosomes.
The development of a dengue virus prM and E proteins directed vaccine is promising as of 2012 whereas previous vaccines have not covered all types. It is usually transmitted by the bite of Aedes aegypti which when infected with wolbachia are less capable virus vectors.