Desmopressin

From Ganfyd

rINN: Desmopressin

Other Names

Desmopressin acetate, DDAVP^®, Presinex^®, Desmotabs^®, Desmospray^®, Nocutil^®

Pharmacological Information

Pharmacology Images

Desmopressin Molecule

Web information on Desmopressin

NHS Evidence on Desmopressin

DrugBank on Desmopressin

Mechanism of Action

• Acts on aquaporins in collecting ducts
• Multiple receptors eg
  • Vasopressin V1b receptor (V1bR)
  • Vasopressin V3 receptor (AVPR V3)

Relevant Clinical Literature

Pubmed on Desmopressin

RCT with Desmopressin

Systematic reviews of Desmopressin

Desmopressin in N Eng J Med, Lancet, JAMA, BMJ

Desmopressin in Cochrane Collaboration

TRIP Database on Desmopressin

Google Scholar on Desmopressin

Bandolier on Desmopressin

UK Guidance

SNOMED search

Nice Guidance on Desmopressin

BNF-registration required
BNF for children-registration required

UK directory of medicines

UK Medicine Guide (eg pictures of capsules)

Centre for Reviews and Dissemination databases -DARE & NHS EED (evaluates reliability of research)

Prodigy Guidance on Desmopressin

Regulatory Literature

UK SPCs of medicines with marketing authorisation

EMEA search

FDA search

Other Literature

PubChem on Desmopressin

CTD (Comparative Toxicogenomics Database) link

ChemIndustry.com link

Protein Structural Information

Biological Information (GenomeNet)

Protein Knowledgebase (UniProtKB)

Please read pharmacological data limitations

Other Wikis

Medpedia on Desmopressin (Less technical, good quality control)

Wikipedia on Desmopressin (Less technical, ? quality control)

Desmopressin is a synthetic analogue of anti-diuretic hormone (ADH)

Desmopressin is used as replacement for ADH in pituitary failure from whatever cause, and in enuresis - in cases where part of the cause is a large volume of urine produced at night.

Side effects

• Headache
• Abdomenal pain
• Nausea
• Rash (rare)