Diabetes insipidus

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Diabetes insipidus is the less common form of diabetes. It is caused by a failure in the kidney to resorb water, or a failure by the pituitary to instruct it to do so. Large volumes of dilute urine are passed, leading to dehydration and collapse.



Can be:

Cranial Diabetes Insipidus

Nephrogenic Diabetes Insipidus

  • Owing to loss of effect of ADH on collecting ducts which can be caused by several mutations in the receptor and effector protein genes (eg in AQP2 or AVPR2).
  • Can be a complication of Conn's syndrome.


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