Differentiation syndrome

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Differentiation syndrome (leukocyte activation syndrome, APL differentiation syndrome) is characterised by:
Web Resources for Differentiation syndrome
Relevant Clinical Literature
Pubmed on Differentiation syndrome
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Systematic reviews of Differentiation syndrome
Differentiation syndrome in N Eng J Med, Lancet, JAMA, BMJ
Differentiation syndrome in Cochrane Collaboration
TRIP Database on Differentiation syndrome
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UK Guidance
NHS Evidence on Differentiation syndrome
Centre for Reviews and Dissemination databases -DARE & NHS EED (evaluates reliability of research)
Nice Guidance on Differentiation syndrome
Prodigy Guidance on Differentiation syndrome
Other Wikis
Medpedia on Differentiation syndrome (Less technical, good quality control)
Wikipedia on Differentiation syndrome (Less technical, ? quality control)
  • Fever
  • Dyspnoea
  • Weight gain
  • Pulmonary infiltrates
  • Pleural or pericardial effusions
  • With or without leukocytosis

It is reduced by systematic prednisone prophylaxis. High dose steroids at first sign of syndrome may improve matters. It can be fatal.

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